Baby Dumpling, the six-year-old son of Blondie and Dagwood Bumstead disappears from sight during his first day at school. While Dagwood frantically combs the city in search of the boy, Baby Dumpling spents a nice, safe afternoon with poor little rich girl Melinda Mason, who with her new playmate's help arises from her sickbed to walk across the room for the first time in months.

Dagwood brings home a pedigreed Great Dane which an important company client wants and which Blondie enters in the big dog show.

The Bumstead family is off to see relatives in the country when Blondie runs into Charlie and Millie, an eloping couple needing her help.

Dagwood Bumstead must receive a college diploma or lose his job with the Dithers Construction Company. Not wishing to be separated from her husband, Blondie enrolls in college as well. But Leighton College rules stipulate "No Married Couples", forcing Blondie and Dagwood to pretend that they're not married. This causes quite a dilemma when coed Laura Wadsworth begins flirting with Dagwood and Rusty Bryant does the same with Blondie. And Blondie's discovery of a very pleasant secret threatens to expose her and Dagwood's marital status too.

Dagwood wants to join the trout club and Blondie wants a fur coat. Jealousy reigns when Dag's old girlfriend Joan shows up, but nothing else matters when a drawing at the movie theatre provides money for the coat.

Mr. Dithers invites the Bumsteads on a South American cruise. Somehow Dagwood winds up as the female drummer in the ship's band, while Penny Singleton gets to show off her Broadway background in some lively musical numbers.

A cop-turned-bail bondsman gets involved in a murder investigation involving a former flame.

Legendary pirate and adventurer Sinbad is in single-minded pursuit of two things: beautiful women and a substance called Greek Fire--an early version of gunpowder.

When newlyweds visit Las Vegas, the wife's shady past comes to the surface.