The town of Downers Grove looks like your average suburban neighborhood -- but Downers Grove has a disturbing secret.... For the past eight years, one senior from every high school graduating class has met a bizarre death right before graduation day. And this year, Chrissie Swanson has a terrible feeling that she is going to be the one to die. Can Chrissie survive the curse of Downers Grove or will she, like those seniors before her, fall prey to the town's deadly secret?

莱姆病经由扁虱叮咬而传染，最初感染症状为出疹子，恶化后将引起关节炎或其他神经性症状。莱姆病在1970年代末期曾在长岛郊区流行。影片讲的就是本就问题多多的两个家庭，因为财产矛盾和莱姆病肆虐，而面临分崩离析的故事。
女孩艾德里·安娜（艾玛·罗伯茨 Emma Roberts 饰）的父亲被确诊出感染了莱姆病，家里入不敷出，妈妈（辛西娅·尼克松 Cynthia Nixon 饰）只好受雇于邻居米奇（亚历克·鲍德温 Alec Baldwin 饰），进而牵扯出米奇一家的种种问题。当两个家庭都陷入了混乱时，艾德里·安娜和米奇的儿子斯考特（罗瑞·库尔金 Rory Culkin 饰）相爱了。然而，他们还来不及享受爱情的甜蜜，一切就在斯考特的哥哥回来之后变得更糟糕了。