故事发生在一座地处偏远的小镇之中，曾经，这里的矿场发生了一起可怕的事故，罪魁祸首是一位名叫汤姆（詹森·阿克斯 Jensen Ackles 饰）的男子。五位无辜的矿工命丧尘土之下，唯一的幸存者哈利则被送往医院急救，陷入了昏迷之中。
　　内疚而又自责的汤姆选择了背井离乡，以逃避这段不堪回首的往事，然而，当他再度踏上故土，却发现曾经的女友萨拉（杰米·金 Jaime King 饰）竟然已经成为了好友埃克瑟尔的妻子。汤姆明白自己内心里对于萨拉旧情难忘，但又无法改变如今令他痛苦万分的现状，与此同时，在医院中苏醒的哈利，手持着鹤嘴锄，决心展开他的复仇计划。

Henry Adler, an outwardly normal banker, yearns to make it in show business and still answers to his overbearing father. When Henry is hired to act in a television police drama, he realizes his big break has arrived and decides to do whatever it takes to get into the role — even if that means donning his police costume in public during off hours. It isn't long, however, before Henry begins to take the law into his own hands as his violent side chillingly emerges.

Rich L.A. party brat Tim spins into a cycle of despair after his parents divorce, and trying to fill the void with drugs and trouble only buys him a ticket to an asylum. But with the help of a psychiatrist who has taken an interest in him, will Tim try to pull himself out of the muck of teenage rebellion and ennui?

秘密、谋杀和鬼魂交织而成的惊悚故事虽然片名如此美丽，但「血色玫瑰」却不是浪漫爱情电影，事实上它是一幢废倾已久豪宅的名称，在她美丽的外表下，隐藏著骇人的残酷血腥。「血色玫瑰」诞生于世纪初，由富豪林鲍夫妇动工兴建，但自建屋起就灾厄不断，不仅多名建筑工人惨死，落成后又有多人接连失踪，前后已有26名人士神秘消逝于「血色玫瑰」的荒烟漫草内。传说这幢房子遭受诅咒，它会自行增建……心理学教授乔伊丝，为了解开这栋位于西捇图的神秘鬼屋之谜，积极地游说六位各具灵媒特质的人士，共同进行一场超心灵实验。他们计划在「血色玫瑰」待上72小时，以揭开这栋传说会吃人房子的神秘面纱。