NYPD Detective Sara Pezzini's main goal in life was to bring down Tommy Gallo, the hitman who killed her father, her best friend, and eventually her partner. While chasing down one of Gallo's thugs, she acquires the Witchblade, an enchanted armored glove once used by Joan of Arc that deflects bullets, extends into bladed weapons, produces visions, and neatly compacts itself into a bracelet.

杜利探员（占士布鲁殊）与他的四脚拍档狗[李谢利]再度出击，迎战高技犯罪势力！杜利即将退休，可惜遇上一幕持械行劫，无端端被当作疑犯，丰厚退休金被冻结。手头拮据的杜利只好硬着头皮后拍档狗合力追缉真凶……