The film centers on Howard F. Howard, an overweight everyman. Engaged to Beverly, the woman of his dreams, Howard has one problem - an overactive fixation with The Three Stooges. Everywhere Howard goes, he sees Moe, Larry, Curly, and Shemp intruding on his life. Determined to overcome his fixation, Howard and Beverly prepare for their wedding. But on his way to the ceremony, Howard descends into Stoogemania and finds himself walking into the city streets with other Stoogemaniacs. His only hope is commitment to the Stooge Hills sanitarium, under the care of a renowned psychologist, until the inmates take over the asylum on graduation day.

Hired to rescue escaped inmates, a Florida man is framed for a Cuban gangster's assassination.

The plot follows series regulars Grandpa Boris and the babies as they become trapped in the attic on Passover; to pass the time, Boris tells the Jewish story of the Exodus. During the episode the babies themselves reenact the story, with young Tommy portraying Moses, while his cousin Angelica represents the Pharaoh of Egypt.

The adults decide to bring the babies and Angelica to Las Vegas on vacation. Tommy convinces the babies to help him find the tigers. Angelica hopes to sing while in Las Vegas.