Waldo Williams returns from his Tijuana vacation to find out that he had become infected by the Notorious Mexican Butt Humping Bullfrog. After being diagnosed by his proctologist with just days to live, Waldo seeks the help of the mysterious Japanese specialist, Dr. Wansamsaki, who treats Waldo with his unorthodox methods, which involve a long nuclear rod. The next day, Waldo’s rear end starts glowing a bright green – and that’s only the beginning. Within days, Waldo’s rear end develops a mind of its own, becoming capable of breaking away in the middle of the night, committing a mur­der or two and then returning before morning, leaving a fecal trail that leads right to Waldo’s bedroom.

Judge Rhinehole orders the Sunny Buttocks Nudist Camp closed down as an affront to the community. Its members enter into a suicide pact, but vow to return for vengeance. Five years later, a group of Christian campers on a retreat argue religion and perform outrageous production numbers as the group begins experiencing an attrition problem.

Chuck Toedan hosts the most controversial show on TV: Live or Die, where deathrow inmates compete against each other for a chance to beat the executioner. However, when he accidentally kills a mob boss of the most feared mafia in the city, a hit man tries to put an end to him and his show once and for all. As a battle of wits and survival ensues, Chuck is forced to engage in the very tactics he uses on his contestants, or die trying.