A 10 year old gifted boy wants to be a jazz pianist much to the chagrin of his more classical oriented piano instructor. With his mother's help, he is an underage regular at a local nightspot, where he is teamed up with a sax superstar. Both come to learn that each suffers from Tourette's Syndrome (thus the film title). The older man has developed mannerisms to cover up his own fallibilities and resents the boy and his mother's acceptance of the disease.

The Naked Brothers Band and another band, the L.A. Surfers, find themselves competing in a "Battle of the Bands" charity event benefiting Little Kids Rock. Rosalina starts to fall for the L.A. Surfers' lead singer, Bobby Love. It annoys Nat that Rosalina hangs out with the opponent's lead singer. It turns out that Bobby is just dating Rosalina to get to Nat and is lying about everything, i.e, his British accent, not writing his own songs, etc. Nat and Bobby fight and declare at a press conference that the charity event is now a competition and the losing band's proceeds from their next CD goes to the charity.

The band's next concert stop is in New Orleans where Nat reunites with a childhood friend, sending Rosalina into a jealous frenzy! Meanwhile, Alex initiates an extreme environmental movement to help save polar bears at the North Pole, but devious reporters frame him to appear as a conceited rock star who hates Santa!

After making it to the top of the charts, members of the Silver Boulders, a popular tween rock band, find themselves undermined by internal squabbling as the bandmates seek different creative directions.