Jonathan Drake, while attending his brother's funeral, is shocked to find the head of the deceased is missing. When his brother's skull shows up later in a locked cabinet, Drake realizes an ancient curse placed upon his grandfather by a tribe of South American Jivaro Indians is still in effect and that he himself is the probable next victim.

十九世纪末，一伙庞大的队伍来到西部的新墨西哥城。这一伙没落的欧洲贵族来这里的目的是狩猎。队伍停留在当地的阿帕奇印第安部落中宿营，起初他们受到阿帕奇人的盛情款待，哪知道后来他们触犯了当地人民，阿帕奇人要把他们处死。队伍中的领头人伯爵夫人埃瑞娜（碧姬.巴铎饰）决定率领自己的队伍和这里的阿帕奇部落展开了反击……