A Boeing 777 arrives at JFK and is on its way across the tarmac, when it suddenly stops dead. All window shades are pulled down. All lights are out. All communication channels have gone quiet. Crews on the ground are lost for answers, but an alert goes out to the CDC. Dr. Eph Goodweather, head of their Canary project, a rapid-response team that investigates biological threats, gets the call and boards the plane. What he finds makes his blood run cold.
In a pawnshop in Spanish Harlem, a former professor and survivor of the Holocaust named Abraham Setrakian knows something is happening. And he knows the time has come, that a war is brewing . . .
So begins a battle of mammoth proportions as the vampiric virus that has infected New York begins to spill out into the streets. Eph, who is joined by Setrakian and a motley crew of fighters, must now find a way to stop the contagion and save his city--a city that includes his wife and son--before it is too late.

Odessa Hardwicke's life is derailed when she's forced to turn her gun on her partner, Walt Leppo, a decorated FBI agent who turns suddenly, inexplicably violent while apprehending a rampaging murderer. The shooting, justified by self-defense, shakes the young FBI agent to her core. Devastated, Odessa is placed on desk leave pending a full investigation. But what most troubles Odessa isn't the tragedy itself-it's the shadowy presence she thought she saw fleeing the deceased agent's body after his death. Questioning her future with the FBI and her sanity, Hardwicke accepts a low-level assignment to clear out the belongings of a retired agent in the New York office. What she finds there will put her on the trail of a mysterious figure named John Silence, a man of enormous means who claims to have been alive for centuries, and who is either an unhinged lunatic, or humanity's best and only defense against unspeakable evil.

Depuis son atterrissage à l'aéroport de JFK à New York, un avion en provenance de Berlin ne répond plus à la tour de contrôle. Le spectacle qu'Ephraïm et son équipe d'épidémiologistes découvrent à bord a de quoi glacer le sang : tous les passagers, sauf quatre, sont morts en apparence paisiblement. Ont-ils été victimes d'un attentat au gaz ? D'une bactérie foudroyante ?

Lorsque, le soir même, deux cents cadavres disparaissent des morgues de la ville, Ephraïm comprend qu'une menace sans précédent plane sur New York. Lui et un petit groupe décident de s'organiser. Et pas seulement pour sauver leurs proches car c'est la survie de l'humanité tout entière qui est en jeu...