The Powerpuff Girls face their greatest challenge in this 10th anniversary special episode. There exists a Key to the World, which is handed from city to city on an annual basis. Whoever possesses the key rules over the entire world. When the key is delivered to Townsville, every villain in Townsville attempts to retrieve it. When the girls procure it for themselves, they quickly get sucked into a power struggle, fighting the villains and themselves over who gets to rule the world.

The Powerpuff Girls must stop Fuzzy Lumpkins

Eight-year-old Mac and his imaginary friend Blooregard Q. Kazoo (or "Bloo" for short) often get into fights with his 13-year-old brother Terrence. When Mac's mother tires of this behavior, she tells him that he has outgrown his age to have an imaginary friend and must get rid of him. Crushed by overhearing their argument, except for Terrence, who is rather pleased, Bloo later comes across a TV commercial for "Foster's Home for Imaginary Friends"--"where good ideas are not forgotten," according to the motto.

The gang must venture into a crazy imaginary world to rescue Frankie when she disappears inside a mysterious box.

American-Canadian animated television series

American animated television series

American animated television series

American animated television series from 1998–2005