'Natural' Davis (William Powell) is a respected gambler who follows a ruthless code of honor with those who cheat against him. His wife, Alma (Kay Francis), wants to divorce him because of his addiction and lifestyle, but they agree on a reconciliation and second honeymoon together and 'Natural' promises to give up gambling. However, his plans change when his brother, 'Babe' (Regis Toomey), arrives in town looking to score big, and 'Natural' has to devise a plan quickly to put him off gambling forever.

In a post-apocalyptic American Frontier, a soldier fends off a brutal warmonger to rescue a girl fated as the savior of humanity.