After struggling and finally conceiving a child, Roxy and Vinnie Ventola, a successful television writing couple, learns that their newborn has AIDS. Soon afterward, the two parents are also diagnosed with the fatal virus.

In New York two detectives of the 87th precinct are initially baffled by the brutal, ritualistic slayings of several young women. Through good detective work and clues left at the crime scenes by the psychopathic killer, they are able to deduce who the killer's next victim will be. A tense chase ensues as they try to prevent him from continuing his bloody rampage