Odile is getting ready to celebrate her birthday. As her kids and grandkids are on their way to visit her, Jean, her husband, unexpectedly passes away.
Unable to cope with reality, she hides him under the bed.

故事围绕塞尔玛展开，当她12岁的儿子路易斯在一次事故后陷入深度昏迷时，塞尔玛悲痛欲绝。当她发现他的“世界末日遗愿清单”时，她意识到路易斯是多么的冒险和有创造力。带着把儿子从悬崖边缘带回来的希望，她决定让他的愿望成真……从日本到葡萄牙，塞尔玛开始了一次冒险，这给了她生活的新理由，也给了她与自己和儿子重新联系的新理由。