One man's quiet suburban life takes a sickening lurch for the worse when a young couple move into the deserted house next door. From the word go it is obvious these are not the quiet professional types who *should* be living in such a nice street. As more and more unbelievable events unfold, our hero starts to question his own sanity... and those of his family.

A social worker tries to get a pimp to change his ways.

Pogue is a private eye with a problem: every morning when he wakes up, he has total amnesia, waking up with a 'blank slate'. Since he is in the middle of a hot investigation and has a developing romance, this is less than convenient.

一名英国特工的儿子被绑架并扣留，索要钻石赎金。特工发现他甚至不能指望那些他认为站在他一边的人来帮助他，所以他决定自己追查绑匪。

戴维（德克·本内迪克特 Dirk Benedict 饰）是一名单纯的大学生，被蛇学家斯通纳（斯特罗瑟·马丁 Strother Martin 饰）相中，成为了他的助手。之后，戴维得知，斯通纳的前任助手莫名失踪了。为了防止戴维被蛇咬伤中毒，斯通纳在戴维开始他的助理生涯之前，为他注射了神秘的血清，对此戴维并无存疑。
斯通纳有一个美丽的女儿名叫克里斯蒂娜（希瑟·孟席斯·乌尔里希 Heather Menzies-Urich 饰），在朝夕相处之间，两个年轻人相爱了。在戴维的身上，渐渐出现了许多奇怪的生理反应，斯通纳安慰他说这只是正常的疫苗副作用而已。一天，戴维在一场畸形秀上看到了半人半蛇的蛇人，他的躯体变化，和戴维身上所发生的变化竟然惊人的相似。

美国德州青年基斯（马特·狄龙 饰）一直以为自已的父亲伟达（吉恩·哈克曼 饰）是个不起眼的平凡老头子。但随着母亲在巴黎的旅程中神秘失踪后， 基斯发现父亲竟是前CIA高层，而母亲的失踪亦被怀疑与CIA有关。在寻找母亲的同时，基斯与伟达更不自觉地卷入一个危险的惊人阴谋中……