The stooge's friend Jerry convinces them to take out on insurance on Curly and then have him act insane to collect. Moe and Larry put Curly on a leash and take him to the insurance doctor and have him act like a dog. Unfortunately, the insurance doctor wants to perform a brain operation (Cerebrum decapitation). The boys try to escape by hiding in the dog catchers wagon, but are caught and taken to the hospital. They escape again, this time by rigging a sheet to a gurney and sailing down the street, where they run into Jerry and knock him into wet cement.

The stooges are singing comedic waiters, enlisted by two doctors to try and cheer up a depressed little girl, whose banker-father has gone missing with $300,000 worth of bonds.

The stooges are private detectives hired to find a missing girl. The boys disguise as pie salesmen and end up wandering around a mad scientist's mansion, trying to find the girl. The boys confront a gorilla and various other bad guys, before rescuing the girl.

The stooges are down and out. With a cop chasing them, they flee into an artists studio where they are mistaken for students. The cop continues to hunt for them and they use a variety of disguises and tactics to elude him. A wild clay throwing fight ends the film.

The boys are stowaways on a train box-car filled with furniture bound for Hollywood where they hope to break into movies and become stars. Arriving at the Carnation Pictures Studios. Fuller Rath, the studio general manager, receives a telegram from the home office telling him that a certain "Mr. Smith and his two assistants" will arrive to take over the supervision of the studios. He mistakes the Stooges as the executives and gives them free reign over the studios, where they proceed to disrupt and destroy the production of a romantic drama.

The stooges join the "Women Haters" club and vow to have nothing to do with the fair sex. Larry marries a girl anyway and attempts to hide the fact from Moe and Curly as they take a train trip.