故事发生在1735年的荷兰好望角，一次偶然中，植物学家尼温（肖恩·史密斯 Shaun Smyth 饰）救下了正在逃跑的黑奴布兰克（鲁斯奈·布朗 Rouxnet Brown 饰），为了报答尼温的救命之恩，布兰克决定同尼温一起前往罗本岛，替尼温效劳。
在罗本岛，布兰克结识了同为努力的荷兰水手杰克彼（尼尔·桑迪兰兹 Neil Sandilands 饰），据说杰克彼是一名同性恋者，因此布兰克对他十分的提防。但随着时间的推移，布兰克渐渐在杰克彼的身上发现了与众不同的闪光点，杰克彼也透过布兰克冷酷的外表发掘出了他善良的内心。一场意料之外的醉酒让布兰克和杰克彼之间的距离迅速拉近，两人之间的感情很快就超越了友谊。

The ghost of "patient zero", who allegedly first brought AIDS to North America - materialises and tries to contact old friends. Meanwhile, the Victorian explorer Sir Richard Burton, who drank from the Fountain of Youth and now works as Chief Taxidermist at the Toronto Natural history Museum, is trying to organise an exhibition about the disease for the museum's "Hall of Contagion".

Drenched in equal measures of joy and grief, this documentary opera - a tribute to the warrior saints of AIDS activism - will make you weep, rage, and sing, maybe all at once. Director John Greyson gleefully riffs on Gertrude Stein's subversive 1934 opera, Four Saints in Three Acts, to create a glorious mélange of palindromes, saints and criminals and a cameo by Queen West's albino squirrel. Winner of a Teddy Award at the Berlin International Film Festival, the film features Toronto's Tim McCaskell, one of the founders of AIDS Action Now, who has been living with AIDS for 25 years and South Africa's Zackie Achmat. HIV-positive, Achmat began a treatment strike in 1999, refusing to take life saving anti-retrovirals until they were accessible to all South Africans. With beautiful rage and a resplendent score by collaborator David Wall, Greyson takes aim at the political vacuum and outrageous greed of pharmaceutical companies that allowed millions to die when they could have lived.