结束了墨西哥的假期，正值青春年少的梅尔（佩顿·里斯特 Peyton List 饰）和茱尔丝（卡梅隆·古德曼 Cameron Goodman 饰）乘夜晚的航班回到洛杉矶。适值深夜，大雨瓢泼，贪图便宜的两个女孩和刚刚认识的青年塞斯（詹姆斯·辛德 James Snyder 饰）、马特（戴夫·鲍尔 Dave Power 饰）搭上一辆深色的机场巴士。除梅尔等人之外，还有一个中年人与他们同行。
四个年轻人相谈甚欢，不知不觉间却被司机（Tony Curran 饰）拉入一条陌生的道路。由于一个意外，巴士半路抛锚。正当众人手忙脚乱之际，司机露出狰狞面目。他收掉他们的手机，并准备实施抢劫。面对这个凶恶的歹徒，她们是该束手就擒，还是伺机逃命呢？

When mysterious alien ships appear in the sky, a scientist is sealed in an underground bunker and must create a bio-weapon to stop the unknown visitors, but paranoia and isolation cause her to question the true intention of her mission.

In the radiation-infected aftermath of World War III, one man's desperate attempt to find his wife in the wastelands that were once the United States inspires his fellow survivors to fight for humanity. The bomb has dropped, and in the blink of an eye, America has been plunged back into the Stone Age. Money is worthless, food is scarce, and those who once thought they were fortunate to survive the initial attack are now slowly being consumed from the inside out, the victims of an all-consuming nuclear scourge. ~ Jason Buchanan, Rovi