A month after the events of 30 Days of Night (2007), prison nurse Sara Maguire is attacked by a vampire during a prisoner transfer and begins to turn, while her ex-cop brother Nick hunts for her, encountering escaped vampire hunter George Fowler along the way.

Former Australian Intelligence operative Victoria Dev Ries, lives a quiet life in suburban America where as a single mother she raises her only daughter and trains fighters in her own M.M.A. gym. But when her daughter goes on a camping trip and fails to return, she is forced to go back into action.

A group of friends embark on a camping trip for a ten-year high school reunion. Their celebration soon turns into a battle for survival when they realize that the locals, who are not what they seem, are hunting them down.