Columbia's 33rd serial (made between "Jack Armstrong" and "The Sea Hound") was based on the character that first appeared in "Action Comics" No. 42.

The East Side boxing champion Muggs answers a challenge to a fight against the West Side champ but just before the match he is kidnapped. His friend Danny Lyons takes his place and wins the fight, only to have Mugs believe that Danny was responsible for his kidnapping.

Rejected by the Army, Marines, and Navy for being too young, the punks help the war effort by throwing fruit at a shop they believe is owned by a Japanese American. Confronted by him wielding a short sword, the gang decides to come back at night but find him dead.

In ridding the area of muggers, the East Side Boys acquire a wealthy benefactor whose privileged son, unbeknownst to him, has fallen in with thugs.

The East Side Kids find a young girl in the apartment of a man who has just been murdered. Believing her to be innocent, they hide her in their clubhouse while they try to find the real killer. The killer, however, used a baseball bat as his murder weapon, and the bat has the fingerprints of one of the gang on it.

A scientist keeps his wife young by killing, stealing the bodies of, and taking the gland fluid from virgin brides.