Set during China's the Warring States Period (476-221 BC), benevolent warrior Chenkang Lu (Joe Odagiri) enters into a torrid love affair with a woman (Maggie Q) from the nomadic Harran tribe. Their relationship sends the warrior to a place where humans were once wolves...

Mushi are beings in touch with the essence of life, far more basic and pure than normal living things. Most humans are incapable of perceiving Mushi and are oblivious to their existence, but there are a few who possess the ability to see and interact with Mushi. One such person is Ginko who travels from place to place to research Mushi and aid people suffering from problems caused by them.