Molly Moo-Cow washes to shore on an island, the one occupied by Robinson Crusoe. Much of the short is Crusoe extolling the virtues of the solitary life, Molly trying to ingratiate herself to Crusoe and Crusoe trying to get rid of her. He finally succeeds-just before cannibals come ashore, capture Crusoe and dump him in a pot. From the time they grab him Crusoe is yelling for help (from whom is unclear, given that he wants the island to himself).

A girl is sewing in her playroom when a boy sneaks in and lets loose a horde of mice into her doll house. She discovers them and is fascinated by them, one in particular who can speak.

The terrible tempered Mr. Bang is commuting to work. When the trolley takes more than 5 seconds to arrive, he follows the tracks to the Skipper's house, where he bets him $10 he won't get to work on time. So motivated, the Skipper cuts breakfast short, but he hasn't paid the bill and his power is off. His wife rigs a sail, which gets him going, but a typhoon blows them off course. They land atop Mr. Bang's train...

A Conestoga Wagon leads Molly Moo-Cow and some ducks through the hills. The ducks stop for a swim by a tepee and go to explore the settlement. Molly misses her friends and goes to look for them; when she finds them she discovers they're behaving like Native Americans, and she joins in. Meanwhile, a Native woman downstream loses her baby in the stream and chases after her. Seeing the baby's in trouble, Molly pursues it as well, and eventually retrieves it.

Blackout gags and music, including the title song originated in the movie musical Gold Diggers of 1933. Hollywood figures caricatured include Tallulah Bankhead, Joan Blondell, James Cagney, Bing Crosby, Guy Kibbee, Zasu Pitts, Mae West, Bert Wheeler and Bob Woolsey, Ed Wynn, George Bernard Shaw, Mussolini, Ben Bernie, The Boswell Sisters and Greta Garbo, who does the "Dat's all, folks!".