We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study.

Robert May's seminal book has played a central role in the development of ecological science. Originally published in 1976, this influential text has overseen the transition of ecology from an observational and descriptive subject to one with a solid conceptual core. Indeed, it is a testament to its influence that a great deal of the novel material presented in the earlier editions has now been incorporated into standard undergraduate textbooks. It is now a quarter of a century since the publication of the second edition, and thorough revision is timely. Theoretical Ecology provides a succinct, up-to-date overview of the field set in the context of applications, thereby bridging the traditional division of theory and practice. It describes the recent advances in our understanding of how interacting populations of plants and animals change over time and space, in response to natural or human-created disturbance. In an integrated way, initial chapters give an account of the basic principles governing the structure, function, and temporal and spatial dynamics of populations and communities of plants and animals. Later chapters outline applications of these ideas to practical issues including fisheries, infectious diseases, tomorrow's food supplies, climate change, and conservation biology. Throughout the book, emphasis is placed on questions which as yet remain unanswered. The editors have invited the top scientists in the field to collaborate with the next generation of theoretical ecologists. The result is an accessible, advanced textbook suitable for senior undergraduate and graduate level students as well as researchers in the fields of ecology, mathematical biology, environmental and resources management. It will also be of interest to the general reader seeking a better understanding of a range of global environmental problems.