Palermo, Sicily, 1984. Examining magistrate Giovanni Falcone allies with Tomasso Buscetta, a former mobster, to defeat the clan of Corleone, the ruthless Mafia faction that rules Cosa Nostra with an iron hand, cruelly eliminating all those who dare to oppose its immense power: other criminals, policemen, judges, even innocent civilians. One of them wants revenge, the other wants justice. But only one can survive such an unequal fight.

During a debate in Naples' town hall in the early 1980s, Pasquale Picone, a former steel-worker who has recently lost his job, sets himself on fire in front of the Municipal Council.