Bud and Doyle are two losers who are doing nothing with their lives. Both of their girlfriends are actively involved in saving the environment, but the two friends couldn't care less about saving the Earth. One day, when a group of scientists begin a mission to live inside a "Bio-Dome" for a year without outside contact, Bud and Doyle mistakenly become part of the project themselves.

In Venice Beach, naive Midwesterner JB bonds with local slacker KG and they form the rock band Tenacious D. Setting out to become the world's greatest band is no easy feat, so they set out to steal what could be the answer to their prayers... a magical guitar pick housed in a rock-and-roll museum some 300 miles away.

When a couple of lazy hunter-gatherers are banished from their primitive village, they set off on an epic journey through the ancient world.

Likeable 6th grader Liam writes to Santa asking him to prove that he's real. But Liam is dyslexic and accidentally sends his letter to Satan instead, who shows up at Liam's house, excited to have his first fanboy letter and wanting a little of Liam's soul.

A pair of buddies conspire to save their best friend from marrying the wrong woman, a cold-hearted beauty who snatches him from them and breaks up their Neil Diamond cover band.