When a mutating, highly contagious fungus escapes a sealed facility, two employees – joined by a grizzled bioterror operative – must survive the wildest night shift ever to save humanity from extinction.

Henry Hackett is the workaholic editor of a New York City tabloid. He loves his job, but the long hours and low pay are leading to discontent. Also, publisher Bernie White faces financial straits, and has hatchet-man Alicia Clark—Henry's nemesis—impose unpopular cutbacks.