Two Sicilian's, Peppe Truzzoliti and Antonio Mancuso, decide, after a misadventure with some mafia drug dealers, to leave the cold and racist Turin to return to their native land. Along for the ride with them is Domenica, a beautiful girl from Veneto, who had arrived in Turin in search of work, but due to a number of setbacks, had been forced into prostitution.

When romantic journalist Paolo rescues American photographer Lizzy from a scuffle in an Italian village, his efforts at romance lead nowhere. But when they meet again in San Francisco, Paolo succeeds in wooing her. Can their love overcome the differences between the traditional Italian Communist and the modern, liberated American woman that threaten to tear the two apart?

Ester finds herself sexually attracted to her newly divorced friend Adele. When Ester admits another love to her hot-headed husband, he searches manically for the rival, who he never suspects is a woman.

After Annunziata (Angela Molina) opens up a hostel with her friend Antonio (Daniel Ezralow), she is saved from being raped by a Camorra boss as the gangster is suddenly killed. The killer escapes before Annunziata is able to see who it was. Following this murder are several others, and always with the same “signature” — a syringe in one of the testicles of the victims. As the gangsters continue to be killed off, the identity of the killer – or killers – slowly becomes obvious.