Based on a notorious Belgian court case, My Friend, or The Hidden Life of Jules Depraeter follows Jules Depraeter, a charming but manipulative businessman from Ghent who becomes entangled in robbery, fraud and conspiracy. When police discover stolen jewels and securities in the trunk of a garage owner linked to him, a complex investigation unfolds. During the trial, Depraeter attempts to save himself by accusing a respected investigating judge of masterminding the crimes and plotting the murder of his own wife. Told through courtroom scenes and flashbacks, the film gradually reveals a web of lies, corruption and psychological manipulation.

Thomas, in his forties, holds an important post in a slaughterhouse. He is engaged to Marie-Rose, the daughter of the director, whom he hopes to follow later. In a routine examination in the hospital, however, he finds out that he has cancer and his days are counted. The upheaval that he suffers as a result, however, does not take long, his decision is certain: he will use the short time to clean up some bad guys. What else can he do now?