Trying to find inspiration for his next horror novel, Blake retreats to the Appalachian Mountains with his mistress, Angelica. Upon arrival they learn about the case of several missing boys in the area. When Angelica follows a lead to one of the missing boys and disappears, Blake becomes a prime suspect.

A high school bus on its way to a retreat blows a tire and stops at the nearest ranch for help. The driver, five troubled students, and their ridiculous gym- teacher chaperone find, instead, criminals who will stop at nothing to make sure their drug operations aren't discovered. The students and teacher are easy prey for these animals, but standing in the way of certain death is a force more determined and more skilled than any of them ever expected: The Bus Driver.