One night in the city. A man attempts to commit suicide from the upper level of a tall building. His action is closely watched by a cowboy and a pin-up girl, both characters on two billboards over the neighbouring buildings.

Tells the parallel stories of nine-year-old Carlitos and his mother, Rosario. In the hopes of providing a better life for her son, Rosario works illegally in the U.S. while her mother cares for Carlitos back in Mexico.