A dirty bomb has decimated New York City’s financial district and reduced midtown to a post-apocalyptic nightmare. The neighborhood known as Slime City has been evacuated, except for the homeless, and in the ruins of a soup kitchen four squatters discover a supply of food that transforms them into hideous slime creatures, driven to murder! Meanwhile, a greedy developer who has set his sights on Slime City hires a team of mercenaries to wipe out the creatures.

A group of homeless misfits must fight for survival when they discover a plot to exterminate every homeless person in the city.