Follow the relationships of a group of husbands and wives that live and love on the same street. While the neighbors come from very different backgrounds, their lives are similar – raising children, dealing with exes, worrying about money and keeping romance in their relationships. But just below the surface — secrets, lies and deception threaten to destroy what they have built.

《神探南茜》衍生剧，根据经典小说改编的此剧由母剧的Josh Schwartz及Stephanie Savage负责创作。剧中讲述一名同性恋的黑人富豪兼发明家，他的父亲卷入了一个科幻﹑难以解释的失踪事件，于是Tom Swift离开自己的舒适圈，踏上寻求真相的路，不过路上可是有光明会想阻碍他。

故事描述了上世纪六十年代所谓的「人类性行为探索者」William Masters和Virginia Johnson的生活及对当时流行文化的影响。据称正是因为这两个人对性爱进行深入研究，才触发了当时西方社会特别是美国的「性革命」。