The series focuses on the 20-something year old anti-hero Johnny C, also known as "NNY" (pronounced 'knee'). He is a deranged serial killer, mass murderer, and spree killer who interacts with various other characters, generally by murdering them. He elaborately kills anyone who even slightly irritates him, then drains their blood and paints one of the walls in his house with it. Johnny is also willing to murder "innocent" people who, in his twisted mind, deserve their fate for some reason or another. The number of Johnny’s victims is in the dozens, if not hundreds — or perhaps even thousands. Authorities are unable to capture Johnny and seem unaware of his existence, even though his crimes are often witnessed in public and reported by the few who manage to survive.

Up in the sky, something...BLUE approaches. And it smells HORRIBLE. Interdimensional creatures have been eating time and using our dimension as a toilet, creating an infinite time poop loop, forcing Dib and ZIM to live the same TERRIBLE day forEVER. They wake, the tuxedo'd pig farts, the world ends. And the key to fixing the loop is GIR. We are all DOOMED... Jhonen Vasquez and Eric Trueheart return to write one final oversized Invader ZIM comic for Oni Press!

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