Stewie是个癫狂的宝贝天才，当他看到电视上有人长的几乎与他一样时，他开始为他统治世界的计划而忧心忡忡。在确信那人是他真正的父亲后，他开始了穿越全国的旅行去寻找他。不过Stewie难以置信的旅行让他更加发觉尿布里的东西的恶心和令人憎恶

斯坦·史密斯是一名驻扎在弗吉尼亚州兰利瀑布城的中央情报局特工，是一名无可争议的武器专家和自豪的热爱家人的男人。斯坦一直对恐怖活动保持警惕，为了保护他心爱的美国和警戒祖国的安全，他会采取极端行为。只要看看他冰箱上的恐怖警报仪，以及每当吐司弹出时他就要对着烤面包机开枪的即时反应就知道了。

The American Dad short film, which preceded the theatrical run of the 2005 feature Fever Pitch, is about Stan Smith touring his work days in the CIA and his "normal" everyday life.

The villains of the Kids Next Door, lead by Father, join forces to resurrect the Ultimate Evil, Grandfather, a tyrant who once ruled the world many years ago when most of the villains were themselves kids. However, Father disgraced him that he can't even try to destroy the KND and the Villains were quickly betrayed when they are turned into Senior Citizombies, creatures that are immortal and can transform any living creature into one of them and slaves who are forced to make Tapioca to refuel Grandfather so he can find and destroy the Book of K.N.D.