Marita, a charming little girl, lives in the country with her grandmother. Her best friend is a modest servant, Anselmo, who almost everyday takes the girl to visit the church known as "Guadalupe's Basilica", an important cathedral in Mexico City, where she discovers Virgin Guadalupe and the legend about her apparitions in that place. Marita doesn't behave properly in school, and her teacher always has a punishment for the girl. She doesn't like school, and she doesn't want to return to school anymore. Besides, Marita's worried about her animals, like a cow who doesn't produce milk. The girl asks many miracles of Virgin Guadalupe, one of them is to not have to go to school. During a visit to the Basilica, Marita hears the Virgin's voice, and this could be the beginning of a responsible life for the girl, like to study and to be a good child.

The film follows adventures of Little Red Riding Hood (Maria Gracia) and Tom Thumb (Cesaro Quezadas) and their friends, fighting against the wicked Witch Queen (Ofelia Guilmáin) and her band of monsters. The film starts at the meeting of the evil monsters in the castle in the Haunted Forest, heart of the Devil's dominion, during which the Vampire (Quintín Bulnes) accuses the Wolf (Manuel Valdés) and the Ogre (José Elías Moreno) of betraying the Witch Queen (La Reina Bruja, renamed Queen of Badness in the English dub), who orders them to ber executed. Their friend Stinky the Skunk (Santanón) however escapes and informs Little Red Riding Hood and Tom Thumb, who promise to help. Meanwhile, the Queen and her sister the Old Witch cast a terrible curse, turning villagers into monkeys and mice for trying to defy her magic. The rest of the story details the heroes' quest to conquer evil.