Doyle Simms grows up across the Hudson from NYC and flees his toxic family to attend a film program there. After a bumpy first year he returns more determined than ever to become a storyteller and figure out his place. Financial setbacks force Doyle to find creative "rent-controlled living" and begin a dual life living out of Penn Station while going to school. We follow Doyle over his college years as he begins to build relationships with several colorful characters such as Saul, a homeless book dealer who shows him the ropes and his own brand of street philosophy, and Allyson, a beautiful, struggling actress he carefully begins to pursue and fall for. Doyle begins to find a weird balance and begin to build a home, but the pressure of maintaining his worlds begins to crack the façade and he's forced to confront his past family demons and reconcile the person he wants to be with the person he is.

Danny is a smart little girl. She lives at the track where her uncle is a horse trainer. She knows her uncle needs just one great horse to make his name.

故事发生在纽约市中心的51号桑树街。某天，地铁上，一名乘客莫名其妙的被一只狂躁的老鼠咬伤了，而在城市的另外一个角落有人也遭到了同样的遭遇。这些被咬的人身体发生了怪异的变化，慢慢的变成了一种新的邪恶的物种。这种物种充满邪恶与力量，具有毁灭一切的欲望，很快病毒就随着老鼠和这种邪恶的怪物蔓延到城市的每个角落。很快，街道上便挤满了这些新生的怪物。
幸存者中退休的拳击手克拉奇（拉里•法森顿 Larry Fessenden 饰）此时与其他六个被从51桑树街驱赶出来的房客正在一所房间中紧张的封门、堵窗，以阻止外面蜂拥而来的异类。究竟他们的挣扎能否拯救这个世界？