NYPD Detective Sara Pezzini's main goal in life was to bring down Tommy Gallo, the hitman who killed her father, her best friend, and eventually her partner. While chasing down one of Gallo's thugs, she acquires the Witchblade, an enchanted armored glove once used by Joan of Arc that deflects bullets, extends into bladed weapons, produces visions, and neatly compacts itself into a bracelet.

A beautiful, schizophrenic, woman is pushed over the edge by her husbands illicit affairs. When her hallucinations become reality, the Devil comes to take his due. Is Miriam insane or has the Devil come to collect on her promise?