Happy Birthday centers around five very different people who share the same birthday as well as varying problems of self-acceptance, family tensions and unrequited love. There is Kelly, a young lesbian whose life is placed in flux by a phone call from a former close friend; Javed, a Pakistani facing deportation and separation from his American lover to his estranged Islamic family; Tracy, a Taiwanese-born former student whose visit from her overbearing mother forces her back into the closet; Ron, a minister who preaches the ability to convert his sexuality, all the while watching gay porn at home; and Jim, an overweight telemarketer whose success at selling diet pills masks his insecurities. As their birthdays approach, these individuals are forced to confront the struggles that stifle their lives.

一宗交通意外，连结两个陌生的人。马克（查克·伯劳姆 Chuck Blaum 饰）在车祸中丧生，一直暗恋他的好友杰夫（亚当·尼尔·史密斯 Adam Neal Smith 饰）因代为回复电邮，认识了马克生前的意大利网友安德烈（亚历山德罗·卡萨 Alessandro Calz a 饰）。安德烈本想取消来德州的计划，但最终被杰夫说服。两个拥有不同人生轨迹的男人，于是带着一点点惆怅和困惑，在阳光如织的德州天空下发生交集。他们真切的分享对逝者的美好回忆，于淡淡的哀鸣中寻找路标前行。
“Ciao”在意大利语里既是“你好”也是“再见”的意思。一个悠长的故事在Ciao中开始，在Ciao中结束，引发了人们强烈的共鸣。生与死，性与爱，得到与失去，就像绵绵的细雨落在全世界的草坪，打湿一颗颗柔软的心。