A young couple plans to have a rockabilly themed wedding out at the old farm, despite warnings of a West Nile Virus outbreak. Things go horribly wrong when the virus spawns zombie-creating mosquitoes, who begin to feed on the wedding guests.

When loser Duke, who has screwed up every hair-brained scheme he's ever come up with, accidentally falls off a cruise ship and wakes up on a mysteriously abandoned, top secret government island, he discovers that it's overrun with mutants and monsters from a failed 1980s DARPA "super soldier" project to stop the 2nd Cold War.