Italian horror fan and academic Calum Waddell speaks with some of the original makers of the controversial horror classic "Cannibal Holocaust" before venturing into the Amazon jungle and surrounding city port, Leticia, to uncover some of the local stories behind the making of the motion picture. What is uncovered, however, leads to a wider and unexpected "true crime" story.

It is the year 2031, as the spores of the Flower of Life spread over the remains of the SDF-1 and SDF-2, the Invid land out of Hyperspace, on a head-on collision with the Earth. They crash on the spot, quickly turning it into their massive hive, later to be called Reflex Point. In a matter of moments, the Invid take control of the devastated planet.