Tweek City is a week in the life of Bill, a potentially closeted, half-Latino, small-time speed dealer in San Francisco's Mission District. Bill is stuck on an endless walk from one empty experience to the next. Only Bill's friend Jerm has the ability to connect and ground him in reality. When Jerm makes an ill-advised stage dive, Bill plunges into a downward spiral that takes him on a nocturnal journey through the streets of San Francisco and ultimately down to Los Angeles where he crashes his high school sweetheart's wedding. From his sleep-deprived, hallucinogenic state, Bill fails miserably in a desperate attempt to reconnect with his first and only love. With nowhere else to go, Bill jacks a car and ends up at the deserted drive-in theater of his childhood where he is forced to confront the ghosts that he had tried to leave behind.

9·11事件之后，美国出台相关政策，严重侵犯了人们的隐私权。政府在全国安置了3000万个摄像头，每天监视人们的一举一动，无论在加油站、更衣室、还是洗手间里，都不能逃脱摄像机的法眼。本片就是以此为灵感，像模像样的导了一出监视剧，通过几个主角的演绎，来展现人们的言行不一。