Jack Morgan is a dog therapist, once famous for being able to read his dog's mind. Although Jack cannot read the minds of other dogs, he still operates a canine mind-reading business, without divulging his inability to customers. Mr. Mooney and his wife bring their dog to see Jack. Dissatisfied with Jack's inability to read his dog's mind, Mr. Mooney, who is a friend of the city mayor, threatens to have his business closed down. After the Mooneys leave, a wealthy man named Clyde Windsor brings his dog, Lucky, to see Jack, who is stunned by his ability to read the dog's mind. He seems worried by this fact and ends the session early. Before Windsor leaves, Jack informs him that Lucky is bothered by three individuals that live with him.

经过一场浩劫，世界上数百万人失踪了－－只是人不见了，他们的衣服、眼镜、隐形眼镜、发夹、助听器、假牙、珠宝、鞋袜……，甚至起搏器和手术针－－都留了下来。
数百万人消失得无影无踪，然而还有更多人留下来。随后，全球发生大混乱－－飞机失事、火车脱轨、汽车相撞、轮船沉没、房屋失火、交通运输瘫痪，无数维修人员也失踪了，悲痛万分的幸存者自杀身亡……这场混乱经过了一段相当长的时间才逐渐平息下来。

真相就在眼前！尼可莱是全球172个国家领袖共同推选出来的世界领袖，其中当然也包括美国总统费兹修。不过有些人对魅力十足的尼可莱心存疑虑，他们认为他就是圣经中的假基督。费兹修遇刺但安然脱险，于是决定找巴克和卡洛琳来调查这起神秘的行刺事件。此时，美国的地下教会却爆发了瘟疫……