Set in 1991 on the inner-city streets of Oakland, California, cocaine dealer Charles Cosby has his life is changed forever when he writes a fan letter to the "Cocaine Godmother" Griselda Blanco, who is serving time at a nearby federal prison. Six months later, Cosby is a multi-millionaire, Blanco's lover, and the head of her $40 million a year cocaine business.

In the 1980s, Andrew McCarthy was part of a young generation of actors who were set to take over Hollywood after a string of successful teen movies. However, when the New York magazine cover story in 1985 dubs them the Brat Pack, stars in the making suddenly find themselves losing control over the trajectory of their careers. Now, almost forty years later, McCarthy looks to reconnect with peers and co-stars so that together they can reflect on their respective legacies.

Terry Goon is keeping strict quarantine in his ex-husband’s Brooklyn brownstone while caring for his nephew — a 19-year-old model from Morocco named Bahlul — bedridden in a full leg cast after an electric scooter accident. Unfortunately for Terry, everyone in his life wants to meet the model.

雷根（克尔斯滕·邓斯特 Kirsten Dunst 饰），吉娜（丽兹·卡潘 Lizzy Caplan 饰）和凯蒂（艾拉·菲舍尔 Isla Fisher 饰）是学生时代的好友，年少时期的轻狂为三个女人带来的美好的回忆，但对另一个女孩贝姬（瑞贝尔·威尔森 Rebel Wilson 饰）来说，事情就完全不同了。原来，心宽体胖的贝姬曾经经常遭到雷根一伙人的嘲笑，她们甚至为她取了“猪脸”这样一个可笑又愚蠢的外号。
时间流逝，贝姬即将结婚的消息犹如一枚炸弹丢到了三个女人的身边，不仅如此，贝姬还邀请了她们来做她的伴娘，“猪脸”都有了老公，三个漂亮的单身女人感到了危机。在婚礼之前，雷根决定为贝姬办一场单身派对，但此时的她不会想到，这个派对会带来怎样的麻烦与疯狂。