South Boston Irish bad boy Danny Quinn returns back home from New York and gets stuck between his pals, who are supported by one Irish mafia clan, and his family, which are members of another.

When a Cincinnati radio station switches from sedate music to top-40 rock 'n' roll, its staff of oddball characters is forced to switch gears quickly. New programming director Andy Travis brings in a new DJ named Venus Flytrap to work with the station's burned-out veteran, Dr. Johnny Fever. Neurotic newsman Les Nessman, eager beaver Bailey Quarters, sleazy salesman Herb Tarlek, blonde bombshell Jennifer Marlowe, who serves as the station's ultra-capable receptionist, and station manager Arthur Carlson, whose domineering mother owns WKRP, round out the eccentric bunch.