Not only must Blondie put on a brave face when her husband Dagwood is fired for the umpteenth time by Mr. Dithers, but she must also tolerate the attention paid to Dagwood by pretty WAC Mary Jane McDermott. A whiz in business matters, Mary Jane sets up Dag in his own business, which replenishes the Bumstead coffers but which drives Blondie into a jealous frenzy.

Dagwood Bumstead poses as his boss Mr. Dithers so that a big business deal can be consummated while Dithers avoids nearsighted process server Jim Gray. The upshot of all this is that Dagwood ends up in a lunatic asylum, forcing Blondie to come to the rescue.

Dagwood accidentally discovers a non-flammable paint. Bad guys Dillon and Stack steal it before he can give it to his boss Radcliffe. To show off his invention, Dagwood paints Radcliffe's house with it and is disgraced when the house burns down!

Baby Dumpling, the six-year-old son of Blondie and Dagwood Bumstead disappears from sight during his first day at school. While Dagwood frantically combs the city in search of the boy, Baby Dumpling spents a nice, safe afternoon with poor little rich girl Melinda Mason, who with her new playmate's help arises from her sickbed to walk across the room for the first time in months.

Dagwood brings home a pedigreed Great Dane which an important company client wants and which Blondie enters in the big dog show.

The Bumstead family is off to see relatives in the country when Blondie runs into Charlie and Millie, an eloping couple needing her help.

Dagwood Bumstead must receive a college diploma or lose his job with the Dithers Construction Company. Not wishing to be separated from her husband, Blondie enrolls in college as well. But Leighton College rules stipulate "No Married Couples", forcing Blondie and Dagwood to pretend that they're not married. This causes quite a dilemma when coed Laura Wadsworth begins flirting with Dagwood and Rusty Bryant does the same with Blondie. And Blondie's discovery of a very pleasant secret threatens to expose her and Dagwood's marital status too.

Dagwood wants to join the trout club and Blondie wants a fur coat. Jealousy reigns when Dag's old girlfriend Joan shows up, but nothing else matters when a drawing at the movie theatre provides money for the coat.

Mr. Dithers invites the Bumsteads on a South American cruise. Somehow Dagwood winds up as the female drummer in the ship's band, while Penny Singleton gets to show off her Broadway background in some lively musical numbers.

Blondie and Dagwood are about to celebrate their fifth wedding anniversary but this happy occasion is marred when the bumbling Dagwood gets himself involved in a scheme that is promising financial ruin for the Bumstead family.

Seaman Hook has big plans for after the war, mostly involving rushing home and marrying his sweetie. So do his fellow seaman, but theirs involve buying bonds.

A young woman jeopardizes the relationship with the man she loves when a no-account from her past shows up.

A high-speed train becomes the star of the film as it rushes from Chicago to Hoover Dam to transport an iron lung to a needy patient.