Art editor Madeleine Damian carries on numerous loveless affairs. After a failed relationship with advertiser Felix Courtland, the increasingly depressed Madeleine attempts suicide. When Jack Garet, her secretary and former lover, tries to blackmail her, Madeleine resigns and seeks a reclusive life. Neighbor David Cousins befriends Madeleine, but soon Courtland and Garet discover her whereabouts and disrupt her new life.

Dr. Laurence, a once-respectable scientist, begins to research the origin of the mind and the soul. The science community rejects him, and he risks losing everything for which he has worked. He begins to use his discoveries to save his research and further his own causes, thereby becoming ... a mad scientist, almost unstoppable.

Songwriters Calhoun and Harrigan get Katie and Lily Blane to introduce a new one. Lily goes to England, and Katy joins her after the boys give a new song to Nora Bayes. All are reunited when the boys, now in the army, show up in England.

When the textile mill closes, putting her out of work, Gracie finds herself experiencing all of the amusements of Blackpool.

White hunter Allan Quartermain and his enigmatic guide help a young Irish woman locate her missing father in unexplored Darkest Africa.