In Renaissance Florence, a Florentine trader meets a shipwrecked stranger, who introduces himself as Tito Melema, a young Italianate-Greek scholar. Tito becomes acquainted with several other Florentines, including Nello the barber and a young girl named Tessa. He is also introduced to a blind scholar named Bardo de' Bardi, and his daughter Romola. As Tito becomes settled in Florence, assisting Bardo with classical studies, he falls in love with Romola.

Daniel Boone Brown is a pleasure-seeking playboy carousing around New York City without a care in the world -- that is, until he becomes the unwitting subject of a series of experiments at the hands of a sadistic psychiatrist.