Filmmaker Emily Wyland reunites with estranged mother for documentary. When mother disappears, Emily and cinematographer Danny pursue clues to her whereabouts amidst traces of her past addictions.

故事描述了上世纪六十年代所谓的「人类性行为探索者」William Masters和Virginia Johnson的生活及对当时流行文化的影响。据称正是因为这两个人对性爱进行深入研究，才触发了当时西方社会特别是美国的「性革命」。