Puta y amada is a comedy that narrates the constant ruptures and reconciliations of Marcos, a film director who is going through a creative crisis, and Adrián, a pop music composer. Both Marcos and his two friends, Zaida and Julia (with whom he shares his love for cinema), embark on a series of superficial relationships, which will make them move from simple selfishness to the revelation and awareness of the loved one, in this moral tale about the end of youth and the desidealization of the world.

Marcos, an unsuccessful film director, is immersed in the shooting of his new film, a queer giallo, when a series of terrible murders starts to happen in Barcelona.