After losing her parents in a tragic accident, Zhuo Yifeng suppresses her past through selective amnesia and takes on a new identity as Su Nianfeng. Raised by her parents' friend alongside his son, Su Muyun, she struggles with an uneasy sibling-like relationship. As she navigates high school, Su Nianfeng finds inspiration in her close friend Yue Diyin, whose warmth and resilience motivate her to pursue a career in medicine despite his battle with a mysterious illness.

The major case squad within the public security organization tackles a series of perplexing cases, led by forensic expert Liao Yan and criminal psychology specialist Liang Maiqi. Both are young professionals returning from abroad, leveraging their expertise to solve unusual cases. Through close collaboration with their teammates, they navigate dangerous situations, using their intelligence and bravery to resolve crises and complete missions. Meanwhile, other young officers in the squad also develop friendships and grow personally through their involvement in solving these intriguing mysteries.