在高级的丹福思寄宿学校，最近发生了一连串奇怪的事件：很多学生无缘无故地病倒了。四名性格各异的女孩——有的聪明过人，有的擅长社交——决定联手展开调查。她们发现这些看似普通的感冒背后，其实隐藏着某种人为的恶作剧或者阴谋。通过观察那些别人忽略的“小细节”，这群少女侦探开始在校园的角落里寻找真相，试图在全校陷入恐慌之前抓住幕后黑手。

Fraternal twin sisters Emma and Lilly are as different as night and day. Emma, the beautiful blonde tomboy, would rather be riding a horse than anything else in the world. While Lilly, her shy redheaded twin, loves to be left alone to curl up with a good book. Emma and Lilly have an insatiable desire to play matchmaker, because their father is actually Cupid. Life gets complicated when they discover they're in love with the same guy and they become bitter rivals as they try to win his affection. But can Emma and Lily overcome their problems and use their matchmaking skills to bring their parents back together?

1986年的5月16日，大衛和桃莉帶著強力炸彈闖進懷厄明州柯克維爾的一所小學，並挾持所有的老師及學生。數小時之後，炸彈被引爆了，但是莫名其妙的是，唯二的死者竟是大衛和桃莉。存活下來的小孩們回家告訴父母，因為當時有許多「白衣天使」教他們如何保護自己，關在教室裡的大家才得以存活下來…

As Christmas approaches, the Buckley brothers decide to fight back against a group of school bullies, the Hagbart's - and their mother joins in too.